Adult cancer patients in England will receive a new game-changing therapy treatment under the first negotiated deal of its kind struck in Europe, NHS England chief executive Simon Stevens announced today.
The CAR-T therapy – Axicabtagene ciloleucel, also known as Yescarta – offers new hope for adult patients whose large cell lymphoma has returned or has stopped responding to previous treatment. It works by re-programming the patient’s own immune system to target their cancer.
CAR T-cell treatments mark the beginning of a new era of personalised medicine, and form part of the NHS’s long term plan to upgrade cancer services.
This is the first time adult NHS patients will have access to CAR-T in lymphoma, and follows a deal NHS England reached last month to make CAR-T available for children and young people with a rare form of leukaemia.
Simon Stevens, chief executive, NHS England said: “Thanks to investment in game-changing techniques like CAR-T, the NHS is at the forefront of providing a new wave of personalised treatments that are individually tailored to patients.
“CAR-T cell therapy is one of the most promising new treatments in a generation for lymphoma and leukaemia, and NHS patients will now be among the first in the world to benefit.
“The NHS has world leading clinicians, researchers and scientists, and today’s announcement is proof-positive that we are open to constructive and flexible partnerships with industry that rapidly bring life sciences innovation to NHS patients in a way that is also fair to British taxpayers.”
Axicabtagene ciloleucel is licenced to treat adult patients with diffuse large B-cell lymphoma and primary mediastinal B-cell lymphoma after two or more previous therapies have failed. Trials indicate that the therapy could potentially cure 40% of patients.
Dr Tobias Menne, Consultant Haematologist at Newcastle’s Northern Centre for Cancer Care said: “This is fantastic news for patients with certain forms of high grade B-cell lymphoma, who previously would have run out of treatment options.
“CAR-T cells are a game-changer for patients with difficult disease and offer very good response rates. This exciting opportunity provides a potential cure to patients.
“We are proud and delighted to be in the first wave of NHS hospitals working towards providing this novel therapy in the near future.”
Hilary Hutton-Squire, General Manager UK and Ireland, Gilead Sciences said: “This is an important day for patients with lymphoma who may have run out of effective treatment options leaving them just months to live. We are delighted to have been able to reach an agreement by working closely with NHS England and NICE which allows us to bring this new generation of personalised cancer treatment to patients.
“This marks many firsts for YESCARTA®; the first sustained reimbursement arrangement, the first full cost-effectiveness analysis in the world, and the first full service design by any government in Europe.
“The speed of this decision shows how research-based life-sciences companies and the NHS can partner together for the benefit of patients in the UK.”
Up to 200 patients a year will receive the treatment after NHS England negotiated a confidential deal with the manufacturer Gilead Sciences.
The treatment would have cost nearly £300,000 per patient at its full list price, but the company’s commercial agreement with NHS England has enabled NICE to approve its entry into NHS England’s Cancer Drugs Fund.
The process of producing such a treatment is complex, and the treatment can produce severe side effects. The treatment is prepared using the patient’s own T cells (a type of white blood cell) that are then modified genetically in a laboratory so that they make a protein called chimeric antigen receptor (CAR).
When the treatment is then given back to the patient, this receptor allows the modified T cells to attach to and kill cancer cells, thereby helping to clear the cancer from the body.
NHS preparations are near completion, meaning CAR-T therapy will be made available in the coming weeks. The first wave of NHS hospitals working towards providing these cutting edge treatments are in:
Cancer survival in this country is now at an all-time high with 7,000 more people surviving cancer compared with three years ago, and the NHS is playing a leading role in the development and adoption of cutting edge technology in a new era of personalised medicine.
So far, CAR-T has only been available to patients in Europe through clinical trials.